Elizabeth Ostler

 Elizabeth Ostler

University of Brighton, United Kingdom

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Elizabeth Ostler's research interests are centred on the use of synthetic and analytical chemistry for intervention in human ageing. 

Her group has been examining the relationship between the rate of formation of advanced glycation end-products (AGEs) and longevity in Drosophila melanogaster using traditional chemical analysis. Whilst AGEs have been subjected to detailed characterisation within the context of mammalian ageing, their precise role remains unclear, partly because intervential experiments in mammalian models are lengthy and expensive.  In contrast, Drosophila melanogaster are short-lived and inexpensive to maintain, but have similar metabolic processes.  Having redeveloped analytical techniques routinely applied to mammalian systems for use in flies, the group are undertaking interventional studies examining how AGE accumulation changes under conditions that extend lifespan.  This work is funded by the EPSRC/BBSRC Strategic Promotion of Ageing Research Capacity network.  

Elizabeth Ostler is also interested in using in vitro assays to evaluate small molecule interventions that may extend healthy life.

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