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1.

Technical Note   Open Access

RVD: a command-line program for ultrasensitive rare single nucleotide variant detection using targeted next-generation DNA resequencing

Anna Cushing, Patrick Flaherty, Erik Hopmans, John M Bell, Hanlee P Ji BMC Research Notes 2013, 6:206 (23 May 2013)

Abstract | Provisional PDF

2.

Research article   Open Access

Self-perceived physical health predicts cardiovascular disease incidence and death among postmenopausal women

Nazmus Saquib, Robert Brunner, Jessica Kubo, Hilary Tindle, Candyce Kroenke, Manisha Desai, Martha L Daviglus, Norrina Allen, Lisa W Martin, Jennifer Robinson, Marcia L Stefanick BMC Public Health 2013, 13:468 (14 May 2013)

Abstract | Provisional PDF | PubMed

3.

Debate   Open Access

Informing DSM-5: biological boundaries between bipolar I disorder, schizoaffective disorder, and schizophrenia

Victoria E Cosgrove, Trisha Suppes BMC Medicine 2013, 11:127 (14 May 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Victoria Cosgrove and Trisha Suppes agree that boundaries between the diagnosis of bipolar disorder I, schizophrenia and schizoaffective disorder are preserved in the DSM-5 criteria, as there is not yet enough data to justify a continuous model of psychosis.

4.

Research   Open Access

Improvements in patient-reported outcomes with apremilast, an oral phosphodiesterase 4 inhibitor, in the treatment of moderate to severe psoriasis: results from a phase IIb randomized, controlled study

Vibeke Strand, David Fiorentino, ChiaChi Hu, Robert M Day, Randall M Stevens, Kim A Papp Health and Quality of Life Outcomes 2013, 11:82 (10 May 2013)

Abstract | Full text | PDF | PubMed

5.

Research   Open Access

Chimeric antigen receptor containing ICOS signaling domain mediates specific and efficient antitumor effect of T cells against EGFRvIII expressing glioma

Chan-Juan Shen, Yu-Xiu Yang, Ethan Q Han, Na Cao, Yun-Fei Wang, Yi Wang, Ying-Ying Zhao, Li-Ming Zhao, Jian Cui, Puja Gupta, Albert J Wong, Shuang-Yin Han Journal of Hematology & Oncology 2013, 6:33 (9 May 2013)

Abstract | Full text | PDF | PubMed

6.

Research   Open Access

Altering physiological networks using drugs: steps towards personalized physiology

Adam D Grossman, Mitchell J Cohen, Geoffrey T Manley, Atul J Butte BMC Medical Genomics 2013, 6(Suppl 2):S7 (7 May 2013)

Abstract | Full text | PDF

7.

Research article   Open Access

Tissue culture-induced genetic and epigenetic alterations in rice pure-lines, F1 hybrids and polyploids

Xiaoran Wang, Rui Wu, Xiuyun Lin, Yan Bai, Congdi Song, Xiaoming Yu, Chunming Xu, Na Zhao, Yuzhu Dong, Bao Liu BMC Plant Biology 2013, 13:77 (5 May 2013)

Abstract | Full text | PDF | PubMed

8.

Research   Open Access

Repetitive and self-injurious behaviors: associations with caudate volume in autism and fragile X syndrome

Jason J Wolff, Heather C Hazlett, Amy A Lightbody, Allan L Reiss, Joseph Piven Journal of Neurodevelopmental Disorders 2013, 5:12 (2 May 2013)

Abstract | Full text | PDF | PubMed

9.

Research article   Open Access

Sodium nitroprusside is not associated with metabolic acidosis during intraoperative infusion in children

Gregory B Hammer, Sara G Connolly, Scott R Schulman, Andrew Lewandowski, Carol Cohane, Tammy L Reece, Ravinder Anand, Jeff Mitchell, David R Drover BMC Anesthesiology 2013, 13:9 (30 April 2013)

Abstract | Full text | PDF | PubMed

10.

Research article   Open Access

Risk factors of short-term mortality after acute nonvariceal upper gastrointestinal bleeding in patients on dialysis: a population-based study

Ju-Yeh Yang, Tsung-Chun Lee, Maria E Montez-Rath, Glenn M Chertow, Wolfgang C Winkelmayer BMC Nephrology 2013, 14:97 (26 April 2013)

Abstract | Full text | PDF | PubMed

11.

Research   Open Access

Notch4 is required for tumor onset and perfusion

Maria José Costa, Xiaoqing Wu, Henar Cuervo, Ruchika Srinivasan, Seth K Bechis, Ellen Cheang, Olivera Marjanovic, Thomas Gridley, Christin A Cvetic, Rong A Wang Vascular Cell 2013, 5:7 (20 April 2013)

Abstract | Full text | PDF | PubMed

12.

Methodology   Open Access

In vivo measurement of apolipoprotein E from the brain interstitial fluid using microdialysis

Jason D Ulrich, Jack M Burchett, Jessica L Restivo, Dorothy R Schuler, Philip B Verghese, Thomas E Mahan, Gary E Landreth, Joseph M Castellano, Hong Jiang, John R Cirrito, David M Holtzman Molecular Neurodegeneration 2013, 8:13 (19 April 2013)

Abstract | Full text | PDF | PubMed

13.

Musings   Subscription Highly Accessed

Are randomized trials obsolete or more important than ever in the genomic era?

John PA Ioannidis, Muin J Khoury Genome Medicine 2013, 5:32 (18 April 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

John Ioannidis and Muin Khoury reflect on how advances in the field of genomics are questioning the need for randomized clinical trials and revolutionizing their design.

14.

Comment   Open Access Highly Accessed

Domesticating the beast

Virginia Walbot BMC Biology 2013, 11:35 (15 April 2013)

Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

In 2009, Virginia Walbot commented ‘Are we training pit bulls to review our manuscripts?’ Revisiting the topic, she asks if we can tame our pit bull reviewers by involving students more in peer review and teaching them to see things from an authors’ perspective and the perspective of the journal that is responsible for making a decision on publication.

15.

Interview   Open Access Highly Accessed

An interview with Patrick O Brown on the origins and future of open access

Patrick O Brown BMC Biology 2013, 11:33 (15 April 2013)

Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

In an interview for the BMC Biology tenth anniversary collection, Patrick O Brown excavates his memory for the origins of open access publishing, and finds a vision of the future still to be fulfilled.

16.

Proceedings   Open Access

NCBO Technology: Powering semantically aware applications

Patricia L Whetzel, Journal of Biomedical Semantics 2013, 4(Suppl 1):S8 (15 April 2013)

Abstract | Full text | PDF

17.

Introduction   Open Access

Selected papers from the 15th Annual Bio-Ontologies Special Interest Group Meeting

Larisa N Soldatova, Susanna-Assunta Sansone, Michel Dumontier, Nigam H Shah Journal of Biomedical Semantics 2013, 4(Suppl 1):I1 (15 April 2013)

Abstract | Full text | PDF

18.

Research   Open Access Highly Accessed

Daily cytokine fluctuations, driven by leptin, are associated with fatigue severity in chronic fatigue syndrome: evidence of inflammatory pathology

Elizabeth Ann Stringer, Katharine Susanne Baker, Ian R Carroll, Jose G Montoya, Lily Chu, Holden T Maecker, Jarred W Younger Journal of Translational Medicine 2013, 11:93 (9 April 2013)

Abstract | Full text | PDF | PubMed

19.

Correction   Open Access

Correction: Mechanisms of stomatal development: an evolutionary view

Anne Vatén, Dominique C Bergmann EvoDevo 2013, 4:11 (4 April 2013)

Abstract | Full text | PDF | PubMed

20.

Comment   Open Access

Open questions: Reflections on plant development and genetics

Virginia Walbot BMC Biology 2013, 11:25 (28 March 2013)

Full text | PDF | PubMed |  Editor’s summary

For the BMC Biology 10th anniversary series of open questions, Virginia Walbot reflects on how genomics has contributed to our understanding of plants over the last ten years, and the challenge of understanding how the flexible phenotypes of plants may adapt to environmental effects in future.

21.

Research article   Open Access Highly Accessed

A systematic review of the care coordination measurement landscape

Ellen M Schultz, Noelle Pineda, Julia Lonhart, Sheryl M Davies, Kathryn M McDonald BMC Health Services Research 2013, 13:119 (28 March 2013)

Abstract | Full text | PDF | PubMed

22.

Research article   Open Access

The buccohypophyseal canal is an ancestral vertebrate trait maintained by modulation in sonic hedgehog signaling

Roman H Khonsari, Maisa Seppala, Alan Pradel, Hugo Dutel, Gaël Clément, Oleg Lebedev, Sarah Ghafoor, Michaela Rothova, Abigael Tucker, John G Maisey, Chen-Ming Fan, Maiko Kawasaki, Atsushi Ohazama, Paul Tafforeau, Brunella Franco, Jill Helms, Courtney J Haycraft, Albert David, Philippe Janvier, Martyn T Cobourne, Paul T Sharpe BMC Biology 2013, 11:27 (28 March 2013)

Abstract | Full text | PDF | PubMed

23.

Meeting report   Free Highly Accessed

The future of genomic medicine is here

Konrad J Karczewski Genome Biology 2013, 14:304 (27 March 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

A report on the 6th annual Future of Genomic Medicine conference, held at the Scripps
Seaside Forum, La Jolla, CA, USA, March 7-8, 2013

24.

Review   Open Access

Drug-induced uveitis

Nikolas JS London, Sunir J Garg, Ramana S Moorthy, Emmett T Cunningham Journal of Ophthalmic Inflammation and Infection 2013, 3:43 (25 March 2013)

Abstract | Full text | PDF | PubMed

25.

Technical Note   Open Access

Cloud-based solution to identify statistically significant MS peaks differentiating sample categories

Jun Ji, Jeffrey Ling, Helen Jiang, Qiaojun Wen, John C Whitin, Lu Tian, Harvey J Cohen, Xuefeng B Ling BMC Research Notes 2013, 6:109 (23 March 2013)

Abstract | Full text | PDF | PubMed

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