Predicting the mechanism of phospholipidosis

An in silico approach was used to predict targets for phospholipidosis, a lysosomal disorder characterized by accumulation of phospholipids in tissues. By predicting targets for a database of compounds, they can be ranked by their potential to cause phospholipidosis

Effect of JNK inhibitors on WS fibroblasts

Two diaminopyridine-based JNK inhibitors were synthesised and their effects on the proliferation and morphology of Werner syndrome fibroblasts were tested, and compared to a widely used JNK inhibitor

Cobalt complex of a microbial oxidation product

The first synthesis of a cobalt cyclopentadienyl diene complex in which the diene has been derived by microbial dearomatising dihydroxylation of an aromatic ring is reported

Exploding Vesicles

A dramatic phenomenon in which light triggers the sudden rupture of fatty acid vesicles has been observed in a primitive cell membrane model, and could lead to applications such as targeted drug delivery

Automated annotation of chemical names

An automated chemical name annotation system has been developed to annotate small molecule names in scientific abstracts with the aim of reproducing MeSH term annotations on biomedical and chemical literature