Determining cinacalcet content in tablets

A novel spectrophotometric quality control method has been reported for the determination of pharmaceutical doses of cinacalcet hydrochloride, a selective calcimimetic agent used to treat hyperparathyroidism and hypercalcemia

The eightfold path to non-enzymatic RNA replication

The original RNA World model is based on the concept of an RNA replicase. However, non-enzymatic RNA replication overcomes some of the problems with this model, and recent findings suggesting that this may have been possible are discussed in this Perspective

Predicting the mechanism of phospholipidosis

An in silico approach was used to predict targets for phospholipidosis, a lysosomal disorder characterized by accumulation of phospholipids in tissues. By predicting targets for a database of compounds, they can be ranked by their potential to cause phospholipidosis

Effect of JNK inhibitors on WS fibroblasts

Two diaminopyridine-based JNK inhibitors were synthesised and their effects on the proliferation and morphology of Werner syndrome fibroblasts were tested, and compared to a widely used JNK inhibitor

Cobalt complex of a microbial oxidation product

The first synthesis of a cobalt cyclopentadienyl diene complex in which the diene has been derived by microbial dearomatising dihydroxylation of an aromatic ring is reported